For nearly two decades, Tango has focused on the intersection between art and science, with a particular focus on health and mental wellbeing. Drawing on her own experiences of anxiety, her installations and performances traverse the embodied self, the emotional terrain of our relationships with others, and the healing possibilities of art. She has collaborated with numerous scientists, health professionals and research institutions, exploring how various aspects of the art-making process can contribute to positive mental wellbeing.

Hiromi Tango's work has been exhibited at major national art museums and regional galleries across Australia. Her work has also featured at international exhibitions in the United States, Belgium, Dubai and throughout Asia Pacific including Singapore, South Korea, Japan, Indonesia and New Zealand. Tango is represented in Australian and international public collections including Artbank, Sydney; Museum of Contemporary Art, Sydney; University of Queensland; and la Maison Folie, Belgium.

Tango's recent solo exhibitions include Hanamida 花涙 ( Flower Tears ), Sullivan+Strumpf 2023; Mother Tongue, Sullivan+Strumpf 2021; New Now, Sullivan+Strumpf 2020; Healing Circles, Sullivan+Strumpf (2019); Healing Chromosomes, Sullivan+Strumpf, Sydney (2017); Art Magic Climbing Tree, Cairns Regional Gallery (2015); Fluorescence, Sullivan+Strumpf, Sydney (2015); Dust Storm, Australian Centre for Photography, Sydney (2014); Hiromi Hotel: Moon Jellies, Casula Powerhouse Arts Centre (2014) and Hazelhurst Regional Gallery and Arts Centre, Sydney (2013); and HOME, with Craig Walsh, Digital Odyssey, Museum of Contemporary Art, Sydney (2011).

Other recent projects and exhibitions include Hiromi Hotel : YU KA 夢花, Bvrisbane Festival (2023); Healing Garden Illawarra, Wollongong Art Gallery (2022); Wheel at Singapore Science Museum (2022); Children’ Sensorium, RMIT, VIC (2022); Wheel, Mental, Science Gallery, Melbourne (2022); Fresh Materials, Townsville City Galleries, Townsville (2022); New Now - Rainbow Meditation Room, Home of the Arts,QLD (2021); Rainbow Magic, TEDxByronBay, NSW (2021); Heartbeat, City Botanic Gardens (2021); Healing Circle - Home, Tweed Regional Gallery, (2019 - 2020); Brisbane Imaginarium: To The Ends of the Earth, Singapore Art Museum, Singapore (2017); ART Jog 10: Changing Perspective, Jogja National Museum, Yogyakarta, Indonesia, (2017); Contour 556: Interventions in the Landscape, Canberra Public Art Festival, Australia, (2016); Public Art Melbourne Biennial Lab: What Happens Now?, Queen Victoria Market (2016); Magic Object, Adelaide Biennial of Australian Art, Art Gallery of South Australia (2016); More Love Hours, Ian Potter Museum of Art, Melbourne (2015); Home - Gwangju, Gwangju Biennale, South Korea (2012); Hiromi Hotel – Mixed Blood, 'Primavera 2011', Museum of Contemporary Art, Sydney (2011); and Behind the Door, Perth Institute of Contemporary Art (2010).